Associate Principal Scientist, Biologics Engineering, Oncology

AstraZeneca operates in over 100 countries and its innovative medicines are used by millions of patients worldwide.

We are looking for an Associate Principal Scientist to join our Biologics Engineering (BE) team based. In this role, you will be responsible for providing critical antibody/protein engineering expertise to support the delivery of our next-generation biotherapeutics portfolio in the Oncology therapeutic area, focusing on Tumour Targeted Delivery. This is a multi-facet role involving independent scientific research and participating and leading projects as part of a multi-disciplinary team. You will also contribute to identifying and developing ground-breaking technologies that benefit biologics drug discovery and have a consistent track record of creatively solving scientific challenges.


AstraZeneca is a global, science-led, patient-focused biopharmaceutical company that focuses on the discovery, development and commercialisation of prescription medicines for some of the world’s most serious diseases. But we’re more than one of the world’s leading pharmaceutical companies.


Welcome to Granta Park Cambridge, UK, one of over 400 sites here at AstraZeneca, providing a collaborative environment where everyone feels comfortable and able to be themselves is at the core of AstraZeneca’s priorities, it’s important to us that you bring your full self to work every day. To help you maintain your best self, here’s a sneak peek into some of the things this site provides for you… Granta Park has a newly built gym with swimming pool, nursery and central food hub accessible to staff as part of the science park facilities. We also have our own bistro and deli in the AstraZeneca buildings. There are regular ‘Lunch & Learn’ events and after work socials with snacks and drinks on the last Friday of every month. This is our biggest and most spacious lab site in Cambridge…come and join us! In Q1 2023, BE will be moving to the new AZ state-of-the-art Discovery Centre (DISC) located on the Cambridge Biomedical Campus.


BE is responsible for discovering and optimizing biological candidate drugs across all AZ therapy areas such as oncology, respiratory and inflammation, cardiovascular, renal, and metabolic diseases.

What you’ll do

  • Develop Antibody Drug Conjugates (ADCs), RadioImmuno Conjugates (RICs), and other therapeutic antibodies or proteins for multiple drug discovery or technology development projects simultaneously, delivering work on time and within budget

  • Identify and lead the development of innovative solutions to engineer and characterize ADCs/RICs and novel formats thereof, and other antibody/protein-based therapeutics

  • Maintain a well-developed understanding of approaches to biologics drug discovery and applies a broader functional knowledge to support the department

  • Lead and provide input to peer-reviewed publications, patents and participate in international conferences

  • Provide technical training and supervise members of the team where required

  • Ensures own work and work of peers follows Good Laboratory Practice, Safety, Health, and Environment standards and all other relevant internal AstraZeneca standards and external regulations

Essential for the role

  • Ph.D. with proven experience or BSc/higher degree with extensive lab-based experience

  • A deep level of knowledge and hands-on experience in antibody/protein engineering

  • Strong technical skills in molecular biology, cell culture, protein expression and purification, and biophysical characterization

  • Good knowledge and experience with in-vitro pharmacology assays

  • A history of successful project delivery and publications, and patents

  • Excellent communication, capable of developing good working relationships with individuals across organizational boundaries, and experience working within a team environment

Desirable for the role

  • Strong project management/leadership skills

  • Previous experience in ADCs/RICs design and development

  • Experience in bioconjugation

Why AstraZeneca?

At AstraZeneca we’re dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit. There’s no better place to make a difference to medicine, patients and society. An inclusive culture that champions diversity and collaboration, and always committed to lifelong learning, growth and development. We’re on an exciting journey to pioneer the future of healthcare.

Close date: 16/08/2022

Competitive salary and benefits

So, what’s next?

  • Are you already imagining yourself joining our team? Good, because we can’t wait to hear from you.

  • Are you ready to bring new ideas and fresh thinking to the table? Brilliant! We have one seat available and we hope it’s yours.

  • If you’re curious to know more then please reach out to Louise Bennett.

Where can I find out more?

Our Social Media, Follow AstraZeneca on LinkedIn

Follow AstraZeneca on Facebook

Follow AstraZeneca on Instagram  

Apply now

Add to shortlist

Login or create a free user account to upload your CV and shortlist jobs.

Create account

Looking for something specific?