Job Title: Senior Scientist; Protein and Cell Sciences- Biologics Engineering
Location: Cambridge (Biomedical Campus)
Salary: Competitive
Fixed- Term Contract – 12 months
Introduction to role:
Join our Biologics Engineering team at the Discovery Centre, Biomedical Campus, Cambridge UK for a fixed term of 1 year. We are seeking a laboratory-based scientist to join our Protein and Cell Sciences team in the department of Biologics Engineering.
As a Senior Scientist, you will provide technical expertise in molecular biology, protein expression (in both prokaryotic and eukaryotic expression systems), protein purification and characterisation. Primary responsibilities will be to produce target proteins (antigens) in support of our Biologics Discovery Portfolio. This will also involve developing techniques and assays to monitor functionality of the recombinant proteins.
Accountabilities:
Provide scientific and technical skills in the area of recombinant target protein production (‘antigens’) to support early and late-stage therapeutic programs.
Applies expertise in producing recombinant expression vectors using standard molecular biology techniques and using these to produce and purify recombinant proteins from bacterial and transient mammalian expression systems (e.g. E.coli, HEK, CHO host cells).
Applies scientific expertise to build robust methods for protein production including development of standard operating procedures.
Develop methods to assay for recombinant protein functionality and integrity.
Makes detailed observations, analyses data, interprets results and maintains laboratory electronic notebooks and databases.
Reporting and presentation of results to project teams and department.
Essential Skills/Experience:
BSc/higher degree with lab-based experience
Already gained experience and technical skills in molecular biology, cell culture, transient protein expression and protein purification.
Proven track record of developing and deploying assays to monitor/assess protein function and quality (e.g. ELISA, Cell based reporter assays) in a laboratory environment.
Excellent communication, capable of developing good working relationships with individuals in team; experience working within a team environment.
Ability to maintain accurate experimental records, databases and use/develop standard operating protocols.
Prior experience in troubleshooting experimental processes relating to protein expression, purification and quality in a laboratory environment.
Desirable Skills:
• Application of automation to laboratory processes in areas of molecular biology and protein expression
When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of three days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.
At AstraZeneca, we follow the science to explore and innovate. We are committed to making a difference by fusing data and technology with the latest scientific innovations to achieve the next wave of breakthroughs. Our inclusive environment allows us to work seamlessly as one, uniting the best from academia, biotech and the industry. We celebrate our successes and failures along the way, driven by our desire to understand and reveal new insights.
Are you ready to embrace new and varied opportunities to develop and learn? This is the place to build a meaningful career as we push the boundaries of science to deliver life-changing medicines. Join us in our mission to impact over one billion patients worldwide!
So, what’s next?
Complete your application before the below closing date.
We welcome your application no later than 23/08/2024
Where can I find out more?
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AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.