Senior Scientist, (Protein Scientist) Biologics Engineering, Oncology

AstraZeneca operates in over 100 countries and its innovative medicines are used by millions of patients worldwide.

We are looking for a Senior Protein Scientist to join our Biologics Engineering (BE) team. In this role, you will support antibody discovery and protein sciences to deliver our next-generation biotherapeutics portfolio in the Oncology therapeutic area, focusing on Tumour Targeted Delivery. In this role, you will craft, lead and conduct laboratory projects/experiments, develop methods, and generate, interpret, and report scientific data. You will also contribute to identifying and developing ground-breaking technologies that benefit biologics drug discovery and have a consistent track record of creatively solving scientific challenges.


AstraZeneca is a global, science-led, patient-focused biopharmaceutical company that focuses on the discovery, development and commercialisation of prescription medicines for some of the world’s most serious diseases. But we’re more than one of the world’s leading pharmaceutical companies.


Welcome to Granta Park Cambridge, UK, one of over 400 sites here at AstraZeneca, providing a collaborative environment where everyone feels comfortable and able to be themselves is at the core of AstraZeneca’s priorities, it’s important to us that you bring your full self to work every day. To help you maintain your best self, here’s a sneak peek into some of the things this site provides for you… Granta Park has a newly built gym with swimming pool, nursery and central food hub accessible to staff as part of the science park facilities. We also have our own bistro and deli in the AstraZeneca buildings. There are regular ‘Lunch & Learn’ events and after work socials with snacks and drinks on the last Friday of every month. This is our biggest and most spacious lab site in Cambridge…come and join us! In Q1 2023, BE will be moving to the new AZ state-of-the-art Discovery Centre (DISC) located on the Cambridge Biomedical Campus.



Biologics Engineering is responsible for discovering and optimizing biological candidate drugs across all AZ therapy areas such as oncology, respiratory and inflammation, cardiovascular, renal, and metabolic diseases. We are constantly pushing the boundaries of science to deliver life-changing medicines to patients, with a passion for developing in-house biologics discovery platforms and novel drug modalities to address unmet medical needs.

What you’ll do

  • Independently lead the planning and execution of complex experimental work to support the Oncology and BioPharma R&D pipeline projects being part of the BE unit, focusing on Antibody Drug Conjugates (ADCs), RadioImmuno Conjugates (RICs), and other antibody/protein-based therapeutics

  • Responsible for molecular biology, biochemistry, and cell biology to provide decision-making data for projects

  • Contribute to multi-disciplinary research drug discovery/technology project teams, effectively communicating forward-looking recommendations and contributing to project team decisions based on their findings, the findings of others, and factors from outside the company

  • Establishes internal and external contacts and collaborations within the scientific field of value to the business and presents findings at internal (intra- and inter-departmental) project team and function meetings

  • Demonstrates solid interpersonal communication by establishing good working relationships with team and department members and others within the company

Essential for the role

  • PhD with relevant experience or BSc/higher degree with equivalent lab-based experience

  • A deep level of knowledge and strong technical skills in molecular biology, cell culture, biochemistry, and protein expression and purification

  • Solid knowledge and hands-on experience with bioinformatics programs (DNA/Protein)

  • Strong expertise in bacterial and mammalian expression systems, AKTA-GE purification systems, and protein characterization techniques such as analytical HP-SEC, mass spectrometry, and thermostability measurements

  • Extensive experience with in-vitro biochemical assays (ELISA, WB, HTRF, SPR (Biacore) or BLI (Octet)) and functional cell-based assays

  • Excellent communication, capable of developing good working relationships with individuals across organizational boundaries, and experience working within a team environment

Desirable for the role

  • Previous experience in next-generation biologics development for oncology, e.g., multi-specific mAbs and ADCs/RICs, would be desirable

  • Experience with stable cell line generation

  • Experience in bioconjugation

  • Experience in bioinformatics and data analysis for integrated data systems (such as Spotfire)

Why AstraZeneca?

At AstraZeneca we’re dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit. There’s no better place to make a difference to medicine, patients and society. An inclusive culture that champions diversity and collaboration, and always committed to lifelong learning, growth and development. We’re on an exciting journey to pioneer the future of healthcare.

Close date: 25/07/2022

Competitive salary and benefits

So, what’s next?

  • Are you already imagining yourself joining our team? Good, because we can’t wait to hear from you.

  • Are you ready to bring new ideas and fresh thinking to the table? Brilliant! We have one seat available and we hope it’s yours.

  • If you’re curious to know more then please reach out to Louise Bennett.

Where can I find out more?

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