TTP Labtech’s new/innovative technology employs a flow principle whereby enzyme and substrate are passed through a thermodynamic cell simultaneously. This allows chipCAL to detect thermodynamic changes using volumes as low as 15µL, minimising the amount of valuable sample used per analysis. chipCAL’s microlitre flow calorimetry also provides the additional benefit of non-contact, label free, sample monitoring.
chipCAL is very easy to use. It has a wide working temperature range of between 15-60°C, allowing a broad range of biological activities to be analysed. Following analysis, samples are simply passed through to a waste unit and a new sample loaded, often without the need for a laborious wash stage. This technology has potential for high throughput enzyme screening, being capable of analysing up to 60 samples in an 8 hour working day.
chipCAL is suitable for monitoring a range of processes in the biopharma, food and fermentation industries
Dr Marcel van Tilborg, corporate scientist, DSM Biotechnology Centre, who has been closely involved in pilot studies using chipCAL said “finally it is possible to achieve fast, label-free and absolute activity measurements - a breakthrough for everyone using enzymes needing speed and accuracy and low cost in biological assays."
For further information on chipCAL, come and visit us at Pittcon, stand 3470, or visit www.ttplabtech.com/new