Ion Channel screening services

Cell Line Optimisation for Ion Channel Screening

The Metrion team has extensive experience of developing, optimising and validating stable cell lines expressing recombinant and endogenous ion channels to help develop robust screening assays.

Ion Channel Screening Assay Development

For more than a decade, Metrion’s scientists have been involved in developing, optimising and validating automated and manual patch clamp assays for ion channel targets. We can fully customise ion channel assays at different stages of the screening cascade, from hit finding and medium throughput structure activity studies, through to specialised biophysical and mechanism-of-action studies for hit series or lead compounds.

Ion Channel Screening Library

We offer validated ion channel screening services against a wide range of ion channels in our library and a variety of  targets available from commercial vendors. We are always seeking to expand our library of ion channel cell lines, please contact us to determine if we can assist you with an ion channel of interest or any of the above services.

Compound Screening

Metrion provide compound screening in both single concentration point and concentration-response formats using our in house library of stable cell lines, client provided cell lines or transiently transfected cells. We also offer our CiPA-compliant cardiac safety panel and translational neuroscience assays.

We offer detailed biophysical studies to characterise compound mechanism of action. Metrion’s scientists have routinely investigated state-dependent inhibition of a variety of voltage-gated ion channels over the last 10 years using both manual and automated patch clamp platforms (e.g. Nav, Cav, hERG and other Kv).

Metrion Biosciences is a UK-based pre-clinical Contract Research Organization (CRO) focused on delivering a range of high quality ion channel drug discovery services. We provide highly skilled electrophysiology screening services to support client medicinal chemistry optimisation programmes, CiPA compliant cardiac safety profiling assays, neuroscience assays and translational assays.