Central phenotypic assay platforms at Metrion include manual patch-clamp and multi-electrode array (MEA) techniques to establish compound target validation, target engagement and species selectivity. Alternatively, these methods can be used to electrophysiologically characterise cells with different etiology. Physiological activity is monitored from native tissue such as rodent cortical neurons or other cell types such as those derived from stem cells.
Metrion Biosciences is a UK-based pre-clinical Contract Research Organization (CRO) focused on delivering a range of high quality ion channel drug discovery services. We provide highly skilled electrophysiology screening services to support client medicinal chemistry optimisation programmes, CiPA compliant cardiac safety profiling assays, neuroscience assays and translational assays.