Research Associate in CRISPR phenotypic screening
The Milner Therapeutics Institute (MTI) at the University of Cambridge aims to accelerate translation of pioneering science into therapies. The newly established Functional Genomics Screening Laboratory (FGSL) at the MTI applies arrayed CRISPR screening in human cellular models to advance mechanistic understanding underlying tissue homeostasis and disease biology. Formed as a joint venture with the Medical Research Council and AstraZeneca, this new laboratory aligns with the MTI's vision of breaking the mould of how academia and industry interact. The FGSL is part of the UK Research and Innovation's Human Functional Genomics Initiative to facilitate innovative and collaborative research to drive new scientific discoveries.
We are seeking to recruit a biologist interested in phenotypic screening to join the FGSL team. You will be applying your expertise in characterising complex models such as stem cells, organoids, primary cells and co-cultures to design and implement arrayed CRISPR screens. The ideal candidate is proficient in developing a range of functional assays such as imaging and flow cytometry to identify key phenotype suitable for high-throughput screening. Previous experience in utilising automated or semi-automated liquid handlers for microplate-based assays is highly desirable.
This is a highly collaborative role where you will work closely with scientists and bioinformaticians from the MTI, AstraZeneca, small/medium enterprises and academic institutions. You will have the opportunity to develop new skills in areas including multi-modality screens, automation platform and bioinformatics analysis.
The MTI is a buoyant, vibrant and fast-paced environment and is ideal for those who thrive in the face of change. We welcome applications from recent PhD graduates or experienced postdocs that are enthusiastic to work as part of a dynamic team at the interface between academia and industry. We offer an engaging and supportive environment that fosters professional growth and career development.
To find out the full duties of the role and person specification, click below to view the further particulars.
Fixed-term: The funds for this post are available for 3 years in the first instance.
Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment.
Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.
Informal enquiries can be directed to Chun Hao Wong, FGSL lead, wc389@cam.ac.uk.
Please quote reference PR43930 on your application and in any correspondence about this vacancy.
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