Salimetrics' newly launched Assay for IL-1β also has the potential to test Vaginal Lavage Fluid. IL-1β is increased in this Mucosal Fluid in women with Sexually Transmitted Diseases. This is not as yet validated.
Interleukin-1β (IL-1β) is one of a family of biologically active small protein molecules known as cytokines. Cytokines are produced by a number of different cell types, including macrophages, monocytes, fibroblasts, and dendritic cells. (1,2,3) IL-1β is an example of a pro-inflammatory cytokine, since it is involved in the body’s inflammatory response to acute or chronic infections, or to conditions that cause a persistent low-grade inflammatory state, such as obesity. (4,5) IL-1β is therefore frequently used as a bio-marker of inflammation. (6,7) A study with normal mouse parotid acinar cells has shown that they synthesize IL-1β and store it in secretory granules. The IL-1β is released from the granules following α- and β-adrenergic stimulation. (8) Relationships between IL-1β levels in blood and saliva are not fully understood.
Salimetrics has just introduced a new immunoassay kit for salivary interleukin-1 beta (IL-1β). IL-1β is widely recognized as a key pro-inflammatory signaling molecule that is involved in multi-directional relationships between many biological systems in the body. With the Salimetrics salivary IL-1β kit, researchers can now reliably measure IL-1 beta in saliva, aiding studies that examine topics such as oral inflammatory diseases, stress and its effects on health, and the nature of relationships between salivary and circulating inflammatory biomarkers. The new salivary IL-1 beta assay makes use of Salimetrics reagents that improve the accuracy of results in saliva.
Salimetrics has completed development of an immunoassay kit that is fully validated for the measurement of interleukin-1 beta (IL-1 β) in saliva samples.
A considerable amount of research is currently being devoted to the study of inflammation, the immune system, and the interaction of these two systems with other major biological systems in the body. Salimetrics is leading the cutting-edge with high-quality salivary assays for inflammatory and immune markers, which researchers can add to their studies alongside the well-respected assays for stress hormones, sex hormones, and autonomic markers that Salimetrics already offers.
The Salimetrics product list currently contains two additional salivary immunoassay kits related to inflammation and immunity: C-reactive protein and secretory IgA. Salivary inflammatory markers IL-6 and TNF-Alpha are currently available through The Salimetrics Laboratory, while commercially available immunoassays are under development. As part of their current focus on markers of inflammation in saliva, The Salimetrics Laboratory will test a full panel of markers: IL-1 beta, IL-6, CRP, TNF-Alpha, and work within the researcher’s existing budget.
IL-1 beta is a key pro-inflammatory signaling molecule released after infection, injury, or antigenic challenge, and is widely used as a biomarker of systemic inflammation. Circulating IL-1 beta is primarily released from immune cells, but it is also secreted from a wide variety of other tissues. IL-1 beta is also present in saliva due to production by immune cells, various oral tissues, and cells in the saliva glands. Some circulating IL-1 beta also finds its way into saliva via the gingival crevicular fluid (GCF) that flows from the gum tissues next to the teeth.
The latest research suggests that salivary levels of IL-1 beta and other cytokines do respond to psychological stress or antigenic challenges outside the oral cavity in a fashion similar to that seen in circulation. This research advises that circulating and oral levels of these markers may be influenced by similar autonomic signaling pathways. IL-1 beta in saliva and GCF already have established uses in studies of periodontitis or other oral diseases, and preliminary studies have suggested that salivary IL-1 beta may also be useful as a marker of psychological stress. Further studies are required to explore the relationships of IL-1 beta and other cytokines in saliva to systemic inflammation and diseases outside the mouth.
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