Applications are invited for a 4-year PhD studentship based in the Department of Chemistry, University of Cambridge and the new AstraZeneca Discovery Centre at Cambridge. The student will be working on a collaborative project jointly supervised by Prof David Spring (Cambridge) and Dr Jonathan Bargh (AstraZeneca) and will have opportunity to work across the two sites.
The project will combine the advances in Antibody-Drug Conjugates (ADCs) with antisense oligonucleotides. ADCs have revolutionized targeted cancer therapy by delivering cytotoxic drugs to cancer cells with reduced systemic toxicity. Concurrently, oligonucleotide-based therapies, such as antisense oligonucleotides, have expanded the therapeutic landscape, offering novel approaches for modulating gene expression and protein function. Antibody-Oligonucleotide Conjugates (AOCs) combine the specificity of antibodies with the gene-modulating capabilities of oligonucleotides. This research aims to develop a novel method for conjugating oligonucleotides to antibodies, utilizing divinylpyridine motifs. The project will involve both organic synthesis and chemical biology skills.
We are looking for a highly motivated and enthusiastic individual capable of thinking and working independently. Applicants must have (or expect to obtain) at least the equivalent of a UK upper second-class Master's degree in a relevant subject such as Chemistry. Ideally, the candidate will have a strong background in organic chemistry. Practical experience of synthetic organic chemistry and peptide chemistry in a research environment would be beneficial.
The studentship commences in October 2025 and provides tuition fees at the UK rate and an enhanced maintenance grant (£21,500 in year 1). Overseas students can be considered if they can cover the difference in the cost of overseas fees. Details of how to apply for University scholarships to cover the extra cost can be found at: https://www.postgraduate.study.cam.ac.uk/
To apply, please submit an application through the University Applicant Portal: https://www.postgraduate.study.cam.ac.uk/courses/directory/pcchpdpch for the course "PhD in Chemistry", naming Professor David Spring as potential supervisor.
For queries relating to your application or the application process, please contact Professor Spring via email on spring@ch.cam.ac.uk.
Please quote reference MA43718 on your application and in any correspondence about this vacancy.
The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.